The new S250 has been developed to enhance the concept of flexibility and automation of the proven S250 Plus, well known for Its robustness and reliabiity. The new version combines established technology with the latest controls and an interchangeable turret.



With the increase of the requirement for the production and development equipment of highly isolated powder treatment, granulation, tablet press, capsule filling and coating, SMA launched the laboratory and production highly isolated containment solid preparation line in time to meet the market demand.

The design of containment equipment must be a risk-based solution which needs a preliminary analysis of key and potential risks for pharmaceutical processes and factory conditions, regulations, layouts, and industrial objectives.

The inlet and outlet of the highly active powder is conducted through the sealing αβ valves. The containment cavity adopts the inflatable sealing, and does not deflate after power off, ensuring complete sealing and production area isolation

The containment cavity is made of stainless steel AISI304, and the micro negative pressure is maintained during production.

The side door is automatically locked and tested when the machine is turned on, and inflatable sealing is used to prevent operators from being hurt by wrong operation.

Clean air passing through primary, medium and high efficiency filters will be sent to the host machine by the pressure fan; the exhaust air disposed by the high efficiency filter through the dust collector and the bag-in-bag-out system and will be discharged to outside. During the whole production process, the host machine cavity is kept with a micro- negative pressure of about -50pa.

All parts in contact with the product will be moistened or cleaned online with more strictly and complex principle before removal according to operational risk control analysis.